Three teenagers are in a critical condition after their car was crushed by a truck in a collision that has shut down a busy road in Melbourne’s north.

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The car collided with a semi-trailer truck in Somerton at about 3.30am on Monday, with four teenage boys cut from the wreckage of their car.

Of the four, three were taken to hospital in a critical condition – while the other also went to hospital.

The truck driver was not hurt and is helping police.

Crash investigators are examining the scene at the intersection of Somerton Rd and Dennis St.