The son of Rob Reiner has been arrested on homicide charges after the filmmaker and ​his wife were found dead in their Los Angeles home, a police official says.

Nick Reiner, 32, was being held in a Los Angeles County jail on a $US4 million ($6 million) ⁠bond, according to jail records.

An official with the Los Angeles County Sheriff’s department said he had been arrested on homicide charges.

Police said they found two bodies at the Reiners’ home at 3.40pm on Sunday (local time) in the Brentwood neighbourhood of Los Angeles on Sunday, whom they did not identify.

Other officials confirmed the victims were Reiner, 78, and his wife Michele, 68.

Local media reported the couple had been stabbed to death.

Just a day after their deaths, US President Donald Trump launched an extraordinary attack on the Hollywood legend.

In a post that has drawn furious condemnation, Trump said the killings were linked to Reiner’s “raging obsession” with him.

“Rob Reiner, a tortured and struggling, but once very talented movie director and comedy star, has passed away, together with his wife, Michele, reportedly due to the anger he caused others through his massive, unyielding, and incurable affliction with a mind crippling disease known as TRUMP DERANGEMENT SYNDROME, sometimes referred to as TDS,” wrote Trump.

“He was known to have driven people CRAZY by his raging obsession of President Donald J. Trump, with his obvious paranoia reaching new heights as the Trump Administration surpassed all goals and expectations of greatness, and with the Golden Age of America upon us, perhaps like never before.

“May Rob and Michele rest in peace!”

Reiner’s son Nick spoke openly over the years about his struggles with substance abuse and about being homeless at times when he was on the run and refusing to go into rehab.

He told People magazine in 2016 that he first went into rehab for drug abuse at the age of 15 — ‌and that he eventually ​had at least 17 stays in rehab facilities.

Rob and Nick Reiner co-wrote the film Being Charlie, based on Nick’s experiences with heroin addiction and homelessness.

“It ‍was the most personal thing I’ve ever been involved in,” Rob Reiner told podcaster Marc Maron in 2016.

Nick told People, “when I was out there, I could’ve died.”

Tributes poured in for Rob Reiner.

“This is a devastating ​loss for our city and our country. Rob Reiner’s contributions reverberate throughout American culture and society, and he has improved countless lives through his ‍creative work and advocacy fighting for social and economic justice,” Los Angeles mayor Karen Bass said.

Reiner’s role as Meathead in Norman Lear’s 1970s TV classic All in the Family, as a progressive foil to O’Connor’s Archie Bunker, catapulted him to fame and won him two Emmy Awards.

Reiner went on to have a prolific Hollywood career as a director, starting with This is Spinal Tap, a 1984 mockumentary about a fictional hard rock band. ​

The film became a cult classic, known for its mostly improvised script, with Reiner playing ‌the faux documentary filmmaker Marty DiBergi.

“That was the trick — to make fun of it and at the same time, honour it,” Reiner told CBS this year as he promoted a sequel, Spinal Tap II: ​The End Continues.

Reiner directed nearly two dozen films in all, including classics such as Stand by Me, a 1986 coming-of-age drama about four boys who set out ‍to find the body of a missing youth, and 1989’s When Harry Met Sally, often cited as one of the greatest romantic comedies of all time.

That movie featured the famed line, “I’ll have what she’s having,” delivered by the director’s real-life mother, Estelle Reiner, reacting to a faked orgasm in a restaurant.

Reiner ​also ​directed the 1987 fairy-tale adventure The Princess Bride, the 1990 psychological thriller Misery ​and the 1992 military courtroom drama A Few Good Men.

The son of comedian Carl Reiner, Reiner was married to photographer Michele Singer Reiner since 1989. The two met while he was directing When Harry Met Sally and had three children together.

Reiner was previously married to actor-director Penny Marshall from 1971 to 1981. He adopted her daughter, Tracy Reiner.

Carl Reiner died in 2020 at age 98 and Marshall died in 2018.

Killings are rare in the Brentwood neighbourhood.

The scene is about 1.5 kilometres from the home where OJ Simpson’s wife Nicole Brown Simpson and her friend Ron Goldman were killed in 1994.

-with AP/AAP